The ability to activate TLD-1433 at both green and red laser wavelengths allows the PDC to be activated at various tissue depths corresponding to the progression of the disease. 

The dark toxicity (TLD-1433, but no laser light applied) was virtually negligible when activated by green laser light and low when activated by red laser light, supporting a high safety margin in the destruction of human pharyngeal carcinoma cells. 

"TLD-1433 continues to advance in the destruction of new oncology targets, demonstrating high efficacy in the destruction of numerous cancers preclinically," Mandel says. "We have strong preclinical data supporting the use of Rutherrin (TLD-1433 + transferrin) in the destruction of glioblastoma brain cancer and lung cancer and now TLD-1433 on its own in the destruction of cervical and pharyngeal cancer."

"The Theralase-licensed PDCs have proven to be very strong anti-cancer drugs in initial clinical studies for NMIBC and preclinically for glioblastoma, lung, cervical, and now pharyngeal cancer," says Roger Dumoulin-White, president and CEO of Theralase. "We look forward to successfully expanding the clinical application of our platform of PDCs, and the laser light systems that activate them, through Phase Ib clinical studies, as we expand into these new oncological targets."